Summary

On 11 March 2020, the World Health Organization declared COVID-19 a global pandemic, and the disease now affects nearly every country and region. Caused by SARS-CoV-2, COVID-19 continues nearly 18 months later to present significant challenges to health systems and public health in both hemispheres, as well as the economies of every country. The morbidity and mortality of the infection caused by SARS-CoV-2 has been significant, and various waves of disease outbreaks initially overwhelmed many hospitals and clinics and continue to do so in many countries. This influences everyone, and public health countermeasures have been dramatic in terms of their impact on employment, social systems, and mental health. This entry collection aims to gather diverse fields about COVID-19, including in epidemiology, public health, medicine, genetics, systems biology, informatics, data science, engineering, sociology, anthropology, nursing, environmental studies, statistics, and psychology.

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Entries
Topic Review
Myocardial Injury Related to SARS-CoV-2 Pneumonia
The diagnosis of SARS-CoV-2 pneumonia is expected to worsen, and mortality will be higher when combined with myocardial injury (MI). The combination of novel coronavirus infections in patients with MI can cause confusion in diagnosis and assessment, with each condition exacerbating the other, and increasing the complexity and difficulty of treatment.
  • 1.4K
  • 08 Oct 2022
Topic Review
Central Role of Gut Microbiota in COVID-19
Alteration in gut microbiota has been observed in COVID-19 patients. However, the underlying mechanisms remain poorly understood. Here, the researchers outlined three potential interconnected pathways leading to gut dysbiosis as an adverse outcome following SARS-CoV-2 presence in the gastrointestinal tract.
  • 1.0K
  • 04 Oct 2022
Topic Review
Utility of Military Teledermoscopy in Pandemic Era
Skin disease remains a common complaint among deployed service members. To mitigate the limited supply of dermatologists in the U.S. Military Health System, teledermatology has been harnessed as a specialist extender platform, allowing for online consultations in remote deployed settings. Operational teledermatology has played a critical role in reductions of medical evacuations with significant cost-savings. When direct in-person lesion visualization is unattainable, teledermoscopy can be harnessed as an effective diagnostic tool to distinguish suspicious skin lesions. Teledermoscopy has the versatile capacity for streamlined incorporation into the existing asynchronous telemedicine platforms utilized worldwide among deployed U.S. military healthcare providers. In terms of clinical utility, teledermoscopy offers a unique and timely opportunity to improve diagnostic accuracy, early detection rates, and prognostic courses for dermatological conditions. Such improvements will further reduce medical evacuations and time away from mission, thereby improving mission readiness and combat effectiveness. As mission goals are safeguarded, associated operational budget costs are also preserved. This innovative, cost-effective technology merits integration into the U.S. Military Health System (MHS).
  • 1.3K
  • 27 Dec 2022
Topic Review
Nucleic Acid-Based Therapies in SARS-CoV-2
SARS-CoV-2 is a coronavirus family member that appeared in China in December 2019 and caused the disease called COVID-19, which was declared a pandemic in 2020 by the World Health Organization. Concerning nucleic acid-based therapy, RNA therapy has shown promising results in treating several human malignances, including viral diseases. There are different approaches to targeting RNA in the human body: small interfering RNAs (siRNAs), microRNAs (miRNAs), antisense oligonucleotides (ASOs), and CRISPR/Cas systems, among others. 
  • 823
  • 30 Sep 2022
Topic Review
Antiviral Drugs Employing Toll-like Receptors in SARS-CoV-2
The innate immune system facilitates defense mechanisms against pathogen invasion and cell damage. Toll-like receptors (TLRs) assist in the activation of the innate immune system by binding to pathogenic ligands. This leads to the generation of intracellular signaling cascades including the biosynthesis of molecular mediators. TLRs on cell membranes are adept at recognizing viral components. Viruses can modulate the innate immune response with the help of proteins and RNAs that downregulate or upregulate the expression of various TLRs. In the case of COVID-19, molecular modulators such as type 1 interferons interfere with signaling pathways in the host cells, leading to an inflammatory response. Coronaviruses are responsible for an enhanced immune signature of inflammatory chemokines and cytokines. TLRs have been employed as therapeutic agents in viral infections as numerous antiviral Food and Drug Administration-approved drugs are TLR agonists. 
  • 1.3K
  • 30 Sep 2022
Topic Review
Virology in Schoolbooks
The researchers have analysed all recent Austrian biology schoolbooks for secondary school with respect to virus-related topics. They found that many books cover many aspects, but books even for the same grade differ greatly in content and detail. Most important, there is a severe lack in clear differentiation between viruses and bacteria, in emphasizing that viruses cannot be destroyed by antibiotics, and in presenting pictures of viruses to show and discuss their structure.
  • 1.1K
  • 28 Sep 2022
Topic Review
COVID-19 Shock Affect Intergenerational Income Mobility
The COVID-19 crisis has caused a huge negative shock to economic activities worldwide, leading to a reduction in income and changes in income distribution. Intergenerational mobility is an important indicator of sustainable social development. 
  • 1.0K
  • 28 Sep 2022
Topic Review
Effect of COVID-19 on Liver
The gastrointestinal tract plays an important role in the pathogenesis of COVID-19. Most patients present with gastrointestinal symptoms and/or abnormal liver function tests, both of which have been associated with adverse outcomes. The mechanisms of liver damage are currently under investigation, but the damage is usually transient and nonsevere. Liver transplantation is the only definitive treatment for acute liver failure and end-stage liver disease, and unfortunately, because of the need for ventilators during the COVID-19 pandemic, most liver transplant programs were temporarily suspended. 
  • 949
  • 26 Sep 2022
Topic Review Peer Reviewed
Simple Formulae, Deep Learning and Elaborate Modeling for the Covid-19 Pandemic
Predictive modelling of infectious diseases is very important in planning public health policies, particularly during outbreaks. This work reviews the forecasting and mechanistic models published earlier. It is emphasized that researchers’ forecasting models exhibit, for large t, algebraic behavior, as opposed to the exponential behavior of the classical logistic-type models used usually in epidemics. Remarkably, a newly introduced mechanistic model also exhibits, for large t, algebraic behavior in contrast to the usual Susceptible-Exposed-Infectious-Removed (SEIR) models, which exhibit exponential behavior. The unexpected success of researchers’ simple forecasting models provides a strong support for the validity of this novel mechanistic model. It is also shown that the mathematical tools used for the analysis of the first wave may also be useful for the analysis of subsequent waves of the COVID-19 pandemic.
  • 2.9K
  • 28 Sep 2022
Topic Review Peer Reviewed
Dental Patients’ Perspective on COVID-19: A Systematic Review
The COVID-19 epidemic has changed patients’ approach to dental treatments. While dentists worldwide have shown an excellent level of adaptability to face the new challenges presented by the unprecedented situation due to the rapid spread of COVID-19, dental patients have witnessed a sudden suspension of elective treatments and a slow resumption of dental care activities after several national lockdowns. In addition, the general climate of anxiety and fear due to the high COVID-19 risk and the high level of mortality has influenced the perception and attitudes of people towards dental activity, inducing many dental patients to avoid appointments to the dentist if not highly urgent. We present an overview of the current state of knowledge about dental patients’ perception, perspective, attitude, and expectations towards a full resumption of regular dental treatments.
  • 3.0K
  • 27 Sep 2022
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