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    (A) Utilizing Boronic Acid-Decorated Polymers for Intracellular Protein Delivery with Polyphenols. Polyphenols play a critical role in enhancing the interaction between polymers containing boronic acid and proteins. In an acidic environment, the pH-responsive catechol–boronate bonds form between the boronic acid-conjugated polymers and polyphenols, enabling the controlled release of RNase. This release can induce cell death by selectively targeting and degrading specific RNA molecules [1]. (B) Enhancing Chemodynamic Therapy (CDT) through the DOX−Den Complex with TA−Fe3+ MPN. The DOX−Den complex efficiently transports doxorubicin (DOX) into cancer cells while evading drug efflux transporters on the cell membrane. Within the cells, DOX is transported to the cell nuclei through the Fenton reaction-mediated CDT. This process leads to the generation of an excess of reactive oxygen species (ROS), ultimately resulting in the elimination of drug-resistant cancer cells [1]. (C) Combining Immune Checkpoint Blockade and Photodynamic Therapy using MMP-2-Sensitive PEGylated EGCG Dimers. PEGylated EGCG dimers and EGCG dimers are utilized to facilitate a novel approach that combines immune checkpoint blockade with photodynamic therapy. Upon activation by MMP-2, the nanoparticles release αPD-L1/ICG, with the antibody effectively blocking the PD-L1 checkpoint. Simultaneously, illumination of the photosensitizer induces multiple effects, including the generation of reactive oxygen species (ROS) and cell death. This innovative approach holds promise for cancer treatment [1].
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