Summary

On 11 March 2020, the World Health Organization declared COVID-19 a global pandemic, and the disease now affects nearly every country and region. Caused by SARS-CoV-2, COVID-19 continues nearly 18 months later to present significant challenges to health systems and public health in both hemispheres, as well as the economies of every country. The morbidity and mortality of the infection caused by SARS-CoV-2 has been significant, and various waves of disease outbreaks initially overwhelmed many hospitals and clinics and continue to do so in many countries. This influences everyone, and public health countermeasures have been dramatic in terms of their impact on employment, social systems, and mental health. This entry collection aims to gather diverse fields about COVID-19, including in epidemiology, public health, medicine, genetics, systems biology, informatics, data science, engineering, sociology, anthropology, nursing, environmental studies, statistics, and psychology.

Expand All
Entries
Topic Review
Impact of SARS-CoV-2 Pandemic on Hepatocellular Carcinoma
Worldwide, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) significantly increases mortality and morbidity. The Coronavirus Disease 2019 (COVID-19) outbreak has had a considerable impact on healthcare systems all around the world, having a significant effect on planned patient activity and established care pathways, in order to meet the difficult task of the global pandemic. Patients with hepatocellular carcinoma (HCC) are considered a particularly susceptible population and conceivably at increased risk for severe COVID-19 because of two combined risk factors: chronic advanced liver disease and HCC itself. In these challenging times, it is mandatory to reshape clinical practice in a prompt way to preserve the highest standards of patient care and safety.
  • 798
  • 25 Aug 2022
Topic Review
SARS-CoV-2 Infection and Rhinologic Manifestation
Many researchers have reported that the nasal cavity is an important initial route for SARS-CoV-2 infection and that the spike protein of this virus binds to angiotensin-converting enzyme 2 (ACE2) on epithelial cell surfaces. Therefore, COVID-19 is thought to significantly affect nasal symptoms and various rhinological diseases. 
  • 726
  • 11 Aug 2022
Topic Review
Electrochemical Biosensing of SARS-CoV-2 Virus for COVID-19 Management
Rapid and early diagnosis of lethal coronavirus disease-19 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an important issue considering global human health, economy, education, and other activities. The advancement of understanding of the chemistry/biochemistry and the structure of the SARS-CoV-2 virus has led to the development of low-cost, efficient, and reliable methods for COVID-19 diagnosis over “gold standard” real-time reverse transcription-polymerase chain reaction (RT-PCR) due to its several limitations. This led to the development of electrochemical sensors/biosensors for rapid, fast, and low-cost detection of the SARS-CoV-2 virus from the patient’s biological fluids by detecting the components of the virus, including structural proteins (antigens), nucleic acid, and antibodies created after COVID-19 infection. 
  • 1.2K
  • 08 Aug 2022
Topic Review
The Main Protease of SARS-CoV-2 and its inhibitors
Mpro, also known as 3-chymotrypsin-like protease (3CLpro), is a 33.8 kDa, three-domain cysteine protease, essential for proteolytic maturation and viral replication of coronaviruses. This enzyme is an excellent target for a potential drug, as it is essential for viral replication and has no closely related homologues in humans, making its inhibitors unlikely to be toxic. 
  • 1.1K
  • 08 Aug 2022
Topic Review
SARS-CoV-2 Intermittent Virulence
Pandemic viruses do not always show decreased virulence. Instead, it appears there is an evolutionary equilibrium between transmissibility and virulence. It can be termed this concept “intermittent virulence”. There is a high possibility that new virulent variants will arise in the near future, although it is improbable that SARS-CoV-2’s virulence will be the same as was seen during the alpha or delta waves, due to the fact that the human population has reached a sufficient level of herd immunity through natural infection or due to the vaccination programs. The most recent global mortality data raised the question of whether this pandemic is really over. Furthermore, it is uncertain when the endemic phase will begin. Darwin’s words: “the survival of the fittest” are still valid, and the virus will continue killing nonvaccinated old people, vaccinated old people, and those with comorbidities.
  • 1.1K
  • 08 Aug 2022
Topic Review
COVID-19 Effect on Fertility
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread over the world, having a huge impact on people’s lives and health. The respiratory system is often targeted in people with the coronavirus disease 2019 (COVID-19). The virus can also infect many organs and tissues in the body, including the reproductive system.
  • 852
  • 03 Aug 2022
Topic Review
Virus Infection and Systemic Inflammation: COVID-19 and Beyond
Respiratory infections with newly emerging zoonotic viruses such as SARS-CoV-2, the etiological agent of COVID-19, often lead to the perturbation of the human innate and adaptive immune responses causing severe disease with high mortality. The responsible mechanisms are commonly virus-specific and often include either over-activated or delayed local interferon responses, which facilitate efficient viral replication in the primary target organ, systemic viral spread, and rapid onset of organ-specific and harmful inflammatory responses. Despite the distinct replication strategies, human infections with SARS-CoV-2 and highly pathogenic avian influenza viruses demonstrate remarkable similarities and differences regarding the mechanisms of immune induction, disease dynamics, as well as the long-term sequelae.
  • 1.0K
  • 05 Aug 2022
Topic Review
COVID-19 in the Brain and Nervous System
COVID-19 can spread throughout the central nervous system, impacting the brain and spinal cord, and neurological symptoms could explain this in people infected with long-term infection.
  • 1.0K
  • 29 Jul 2022
Topic Review
Celiac Disease in Children during COVID Pandemic
Celiac disease is a chronic inflammatory disease that primarily affects the small intestine following the ingestion of gluten and the related prolamins found in wheat, rye, oats, and barley. It has a prevalence in the general population worldwide of approximately 1%.
  • 1.1K
  • 25 Jul 2022
Topic Review
Factors Influencing Choices Intention of Online Learning COVID-19
Since the COVID-19 outbreak, online learning has become the norm. Primary school students require parental assistance and supervision due to their lack of digital media capabilities and safety concerns. Online learning experiences during the pandemic will affect future parents' choices of online learning, so it is necessary to further clarify the key factors influencing parents' perceptions and attitudes towards online learning during the pandemic. In the post-pandemic era, blended learning, which combines traditional school learning with online learning, is likely to become a common and acceptable way of learning, and parents may face multiple choices of their parents' way of learning.
  • 1.8K
  • 27 Jul 2022
  • Page
  • of
  • 74

Other Entry Collections

>>