Summary

HandWiki is the world's largest wiki-style encyclopedia dedicated to science, technology and computing. It allows you to create and edit articles as long as you have external citations and login account. In addition, this is a content management environment that can be used for collaborative editing of original scholarly content, such as books, manuals, monographs and tutorials.

Expand All
Entries
Topic Review
Frost Diagram
A Frost diagram or Frost–Ebsworth diagram is a type of graph used by inorganic chemists in electrochemistry to illustrate the relative stability of a number of different oxidation states of a particular substance. The graph illustrates the free energy vs oxidation state of a chemical species. This effect is dependent on pH, so this parameter also must be included. The free energy is determined by the oxidation–reduction half-reactions. The Frost diagram allows easier comprehension of these reduction potentials than the earlier-designed Latimer diagram, because the “lack of additivity of potentials” was confusing. The free energy ΔG° is related to reduction potential E in the graph by given formula: ΔG° = −nFE° or nE° = −ΔG°/F, where n is the number of transferred electrons, and F is Faraday constant (F = 96,485 J/(V·mol)). The Frost diagram is named after Arthur Atwater Frost (de), who originally created it as a way to "show both free energy and oxidation potential data conveniently" in a 1951 paper.
  • 6.5K
  • 01 Dec 2022
Topic Review
Anki
Anki (/ˈɒŋkiː/; Japanese: [aŋki]) is a free and open-source flashcard program using spaced repetition, a technique from cognitive science for fast and long-lasting memorization. "Anki" (暗記) is the Japanese word for "memorization". The SM-2 algorithm, created for SuperMemo in the late 1980s, forms the basis of the spaced repetition methods employed in the program. Anki's implementation of the algorithm has been modified to allow priorities on cards and to show flashcards in order of their urgency. The cards are presented using HTML and may include text, images, sounds, videos, and LaTeX equations. The decks of cards, along with the user's statistics, are stored in the open SQLite format.
  • 7.0K
  • 01 Dec 2022
Topic Review
BRCA Mutation
A BRCA mutation is a mutation in either of the BRCA1 and BRCA2 genes, which are tumour suppressor genes. Hundreds of different types of mutations in these genes have been identified, some of which have been determined to be harmful, while others have no proven impact. Harmful mutations in these genes may produce a hereditary breast–ovarian cancer syndrome in affected persons. Only 5–10% of breast cancer cases in women are attributed to BRCA1 and BRCA2 mutations (with BRCA1 mutations being slightly more common than BRCA2 mutations), but the impact on women with the gene mutation is more profound. Women with harmful mutations in either BRCA1 or BRCA2 have a risk of breast cancer that is about five times the normal risk, and a risk of ovarian cancer that is about ten to thirty times normal. The risk of breast and ovarian cancer is higher for women with a high-risk BRCA1 mutation than with a BRCA2 mutation. Having a high-risk mutation does not guarantee that the woman will develop any type of cancer, or imply that any cancer that appears was actually caused by the mutation, rather than some other factor. High-risk mutations, which disable an important error-free DNA repair process (homology directed repair), significantly increase the person's risk of developing breast cancer, ovarian cancer and certain other cancers. Why BRCA1 and BRCA2 mutations lead preferentially to cancers of the breast and ovary is not known, but lack of BRCA1 function seems to lead to non-functional X-chromosome inactivation. Not all mutations are high-risk; some appear to be harmless variations. The cancer risk associated with any given mutation varies significantly and depends on the exact type and location of the mutation and possibly other individual factors. Mutations can be inherited from either parent and may be passed on to both sons and daughters. Each child of a genetic carrier, regardless of sex, has a 50% chance of inheriting the mutated gene from the parent who carries the mutation. As a result, half of the people with BRCA gene mutations are male, who would then pass the mutation on to 50% of their offspring, male or female. The risk of BRCA-related breast cancers for men with the mutation is higher than for other men, but still low. However, BRCA mutations can increase the risk of other cancers, such as colon cancer, pancreatic cancer, and prostate cancer. Methods to diagnose the likelihood of a patient with mutations in BRCA1 and BRCA2 getting cancer were covered by patents owned or controlled by Myriad Genetics. Myriad's business model of exclusively offering the diagnostic test led to Myriad growing from being a startup in 1994 to being a publicly traded company with 1200 employees and about $500M in annual revenue in 2012; it also led to controversy over high prices and the inability to get second opinions from other diagnostic labs, which in turn led to the landmark Association for Molecular Pathology v. Myriad Genetics lawsuit.
  • 1.7K
  • 01 Dec 2022
Biography
Jalāl al-Dīn Muḥammad Rūmī
Jalāl al-Dīn Muḥammad Rūmī (Persian: جلال‌الدین محمد رومی‎), also known as Jalāl al-Dīn Muḥammad Balkhī (جلال‌الدین محمد بلخى), Mevlânâ/Mawlānā (Persian: مولانا‎, lit. 'our master') and Mevlevî/Mawlawī (Persian: مولوی‎, lit. 'my master'), but more popularly known simply as Rumi (30 September 1207 – 17 December 1273), wa
  • 8.7K
  • 05 Dec 2022
Topic Review
Solution-Focused Brief Therapy
Solution-focused (brief) therapy (SFBT) is a goal-directed collaborative approach to psychotherapeutic change that is conducted through direct observation of clients' responses to a series of precisely constructed questions. Based upon social constructionist thinking and Wittgensteinian philosophy, SFBT focuses on addressing what clients want to achieve without exploring the history and provenance of problem(s). SF therapy sessions typically focus on the present and future, focusing on the past only to the degree necessary for communicating empathy and accurate understanding of the client's concerns. SFBT is future-oriented and goal-oriented interviewing technique that helps clients "build solutions." Elliot Connie defines solution building as "a collaborative language process between the client(s) and the therapist that develops a detailed description of the client(s)' preferred future/goals and identifies exceptions and past successes". By doing so, SFBT focuses on clients' strengths and resilience.
  • 4.7K
  • 01 Dec 2022
Topic Review
Agency (LDS Church)
Agency (also referred to as free agency or moral agency), in the theology of The Church of Jesus Christ of Latter-day Saints (LDS Church), is "the privilege of choice which was introduced by God the Eternal Father to all of his spirit children in the premortal state". Mortal life is viewed as a test of faith, where our choices are central to the plan of salvation in Latter-day Saint teaching. "It was essential for their eternal progression that they be subjected to the influences of both good and evil". LDS Church members believe that Lucifer rebelled against the God's plan, which resulted in a war in heaven, and Lucifer being cast out of heaven and becoming Satan. Church members believe that all individuals have the ability to differentiate between good and evil and that Satan and his followers are not able to tempt people beyond the point where they can resist. This implies that mortals can be held accountable for their actions; mortals will be judged by God based on a combination of one's faith and works (with salvation coming only through the power, mercy, and grace of Jesus Christ).
  • 1.6K
  • 01 Dec 2022
Topic Review
Term (Logic)
In mathematical logic, a term denotes a mathematical object while a formula denotes a mathematical fact. In particular, terms appear as components of a formula. This is analogous to natural language, where a noun phrase refers to an object and a whole sentence refers to a fact. A first-order term is recursively constructed from constant symbols, variables and function symbols. An expression formed by applying a predicate symbol to an appropriate number of terms is called an atomic formula, which evaluates to true or false in bivalent logics, given an interpretation. For example, [math]\displaystyle{ (x+1)*(x+1) }[/math] is a term built from the constant 1, the variable x, and the binary function symbols [math]\displaystyle{ + }[/math] and [math]\displaystyle{ * }[/math]; it is part of the atomic formula [math]\displaystyle{ (x+1)*(x+1) \ge 0 }[/math] which evaluates to true for each real-numbered value of x. Besides in logic, terms play important roles in universal algebra, and rewriting systems.
  • 924
  • 01 Dec 2022
Topic Review
Luciferianism
Luciferianism is a belief system that venerates the essential characteristics that are affixed to Lucifer, the name of various mythological and religious figures associated with the planet Venus. The tradition, influenced by Gnosticism, usually reveres Lucifer not as the devil, but as a destroyer, a guardian, liberator, light bringer or guiding spirit to darkness, or even the true god as opposed to Jehovah.
  • 37.4K
  • 01 Dec 2022
Biography
John Bowlby
Edward John Mostyn Bowlby, CBE, FRCP, FRCPsych (/ˈboʊlbi/; 26 February 1907 – 2 September 1990) was a British psychologist, psychiatrist, and psychoanalyst, notable for his interest in child development and for his pioneering work in attachment theory. A Review of General Psychology survey, published in 2002, ranked Bowlby as the 49th most cited psychologist of the 20th century.[1][2][3]
  • 4.4K
  • 01 Dec 2022
Topic Review
Environment Modules
The Environment Modules system is a tool to help users manage their Unix or Linux shell environment, by allowing groups of related environment-variable settings to be made or removed dynamically. Modules has been around since the early 1990s and is used at some of the largest computer centers to deploy multiple versions of different software tools to users. The National Energy Research Scientific Computing Center (NERSC) reports that they use Environment Modules to manage nearly all software. Environment Modules is specified as a Baseline Configuration requirement of the DoD High Performance Computing Modernization Program (HPCMP) Project Baseline Configuration team for participating DoD Supercomputing Resource Centers (DSRCs).
  • 898
  • 01 Dec 2022
  • Page
  • of
  • 863

Other Entry Collections

>>