Summary

On 11 March 2020, the World Health Organization declared COVID-19 a global pandemic, and the disease now affects nearly every country and region. Caused by SARS-CoV-2, COVID-19 continues nearly 18 months later to present significant challenges to health systems and public health in both hemispheres, as well as the economies of every country. The morbidity and mortality of the infection caused by SARS-CoV-2 has been significant, and various waves of disease outbreaks initially overwhelmed many hospitals and clinics and continue to do so in many countries. This influences everyone, and public health countermeasures have been dramatic in terms of their impact on employment, social systems, and mental health. This entry collection aims to gather diverse fields about COVID-19, including in epidemiology, public health, medicine, genetics, systems biology, informatics, data science, engineering, sociology, anthropology, nursing, environmental studies, statistics, and psychology.

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Topic Review Peer Reviewed
COVID-19: Evidenced Health Disparity
Health disparity is an unacceptable, unjust, or inequitable difference in health outcomes among different groups of people that affects access to optimal health care, as well as deterring it. Health disparity adversely affects disadvantaged subpopulations due to a higher incidence and prevalence of a particular disease or ill health. Existing health disparity determines whether a disease outbreak such as coronavirus disease 2019, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), will significantly impact a group or a region. Hence, health disparity assessment has become one of the focuses of many agencies, public health practitioners, and other social scientists. Successful elimination of health disparity at all levels requires pragmatic approaches through an intersectionality framework and robust data science.
  • 3.8K
  • 13 Apr 2022
Topic Review
Melatonin Safety and Therapeutic Efficacy
Viral infections constitute a tectonic convulsion in the normophysiology of the hosts. The current coronavirus disease 2019 (COVID-19) pandemic is not an exception, and therefore the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, like any other invading microbe, enacts a generalized immune response once the virus contacts the body. Melatonin is a systemic dealer that does not overlook any homeostasis disturbance, which consequently brings into play its cooperative triad, antioxidant, anti-inflammatory, and immune-stimulant backbone, to stop the infective cycle of SARS-CoV-2 or any other endogenous or exogenous threat. In COVID-19, the corporal propagation of SARS-CoV-2 involves an exacerbated oxidative activity and terefore the overproduction of great amounts of reactive oxygen and nitrogen species (RONS). The endorsement of melatonin as a possible protective agent against the current pandemic is indirectly supported by its widely demonstrated beneficial role in preclinical and clinical studies of other respiratory diseases. 
  • 837
  • 03 Aug 2021
Topic Review
Student Performance in MOOCs
COVID-19 has drastically changed human life, both in the current era and, no doubt, in the years to come. One of the hot topics during this period is whether and how COVID-19 will change education patterns in the next few years. This entry aimed to investigate the relationship between massive open online courses (MOOCs) and students’ learning performance. To that end, this entry combined the gamification concept with the modified information systems (IS) success model and the expectation–confirmation model (ECM) for building a research model. We surveyed 586 students through an online survey and tested the hypotheses. The results indicated that MOOCs’ information quality (IQ), system quality (SQ), and service quality (SEQ) had positive influences on the confirmation, which then affected MOOCs’ usefulness, satisfaction, and gamification. Students’ continued usage intention and course performance were positively influenced by usefulness and gamification. Students’ continued usage intention of MOOCs also positively affected course performance. The relationship between gamification and satisfaction, however, was not proved. The results also showed that gamification, which was composed of entertainment, challenge, and social interaction, played a critical role in improving students’ continued usage intention of MOOCs and their course performance.
  • 997
  • 13 Aug 2021
Topic Review
COVID-19 Pandemic Impact Tourism Stakeholder
The impact of the COVID-19 pandemic on the tourism industry is still sustained, and the response of the tourism industry is an indispensable element that is increasingly recognized. This response has led to the emergence of literature about the impact of COVID-19 on the stakeholders of the tourism industry, thereby contributing to the industry. Nonetheless, criterion factors and investigated practices on the implementation of decision-making by stakeholders in the tourism industry have not been fully explored. Practically, the irresistible risk industry is already synonymous with tourism. Indeed, it is an unstable industry. 2003, 2 million tourists reduce of SARS. 2009, Global Economic Crisis tourist 37 million reduce. 2020, the COVID-19 pandemic, the world's borders are blocked, all international travel is stopped, and the mobility of tourists is prohibited. However, effective decision-making is lacking, and few studies have determined the solutions in the tourism industry of stakeholder. How the tourism industry survives under the crisis context is an urgent issue.
  • 2.9K
  • 11 Aug 2021
Topic Review
Nasal Air Conditioning and SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as with the influenza virus, has been shown to spread more rapidly during winter. Severe coronavirus disease 2019 (COVID-19), which can follow SARS-CoV-2 infection, disproportionately affects older persons and males as well as people living in temperate zone countries with a tropical ancestry. The available data are consistent with optimal warming and humidifying of inspired air by the nose (nasal air conditioning) being essential for minimising SARS-CoV-2 infectivity of the upper respiratory tract (URT)  and, as a consequence, severe COVID-19. 
  • 1.3K
  • 04 Jan 2022
Topic Review
Marine Resources for COVID-19 Treatment
Marine resources have significant pharmacological potential in combatting various diseases, such as COVID-19. The wide variety of marine bioactive compounds and their implications are extensive. Micro and macro-organisms produce inorganic polyphosphates, sulfated polysaccharides, Bromotyrosines and many more. These compounds possess unique properties that allow them to combat Sars-Cov-2 infection, proving as efficacious potential therapeutics. Despite the challenges faced, marine organisms serve as a promising avenue for future pharmacological intervention. The present review for the first time highlights marine bioactive compounds, their sources, and their anti-viral mechanisms of action, with a focus on potential COVID-19 treatment.
  • 1.2K
  • 27 Jul 2021
Topic Review
COVID-19 Vaccines in Multiple Sclerosis
Understanding the risks of COVID-19 in patients with Multiple Sclerosis (MS) receiving disease-modifying therapies (DMTs) and their immune reactions is vital to analyze vaccine response dynamics. A systematic review on COVID-19 course and outcomes in patients receiving different DMTs was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Emerging data on SARS-CoV-2 vaccines was used to elaborate recommendations.
  • 1.1K
  • 27 Jul 2021
Topic Review
Vitamin C and Kidney Injury
Vitamin C is an important micronutrient and antioxidant for the human body.  In animal experiments, it can protect the kidneys from injury caused by nephrotoxic drugs.  A major feature of COVID-19 and similar viral infection is the cytokine storm, which causes a rise of multiple cytokines in the blood. Those cytokines result in the oxidative stress in cells, which leads to damage to organs and tissues, including the kidneys.  Here, we reviewed the current literature on kidney damage in COVID-19 patients and analyzed the possible etiology and mechanisms.  In addition, we summarized the potential use of vitamin C in preventing kidney damage in experimental animal models and the underlying mechanisms.  Vitamin C appears to protect and facilitate recovery of kidneys from injuries derived from excessive of oxidative stress, a feature of cytokines storm in people with COVID-19.  Finally, we would like to argue that vitamin C may be protective of the renal functions in COVID-19 patients with pre-existing kidney diseases. 
  • 1.8K
  • 26 Jul 2021
Topic Review
Sonic Environment and Noise Mitigations
The pandemic has impacted every facet of our life, society, and environment. It has also affected both the requirement and challenges for acoustic research and applications. The present article attempts to present a summary of the impact of COVID-19 on several aspects of acoustics, from the changes in the sonic environment due to reduced human and industrial activities to natural ventilation requirements for mitigating the transmission of coronavirus while mitigating noise, and, more importantly, discusses the potential impacts and challenges for acoustics in the post-COVID-19 era. The present study specifically examines the effects of COVID-19 on the sonic environment, the acoustic treatment by considering the need for constant disinfection, the noise control on construction and neighborhood activities in response to an increased number of people working from home, and the need for having natural ventilation while mitigating noise at home and offices. 
  • 1.4K
  • 26 Jul 2021
Topic Review
Walking Needs and COVID-19
More than 150 cities around the world have expanded emergency cycling and walking infrastructure to increase their resilience in the face of the COVID 19 pandemic. This tendency toward walking has led it to becoming the predominant daily mode of transport that also contributes to significant changes in the relationships between the hierarchy of walking needs and walking behaviour. These changes need to be addressed in order to increase the resilience of walking environments in the face of such a pandemic.
  • 951
  • 26 Jul 2021
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